I agree Rakoonic, and this is exactly how I do things. I would much rather work from the top left like I’m used to. Especially with all the headers and things like that. As long as you know the actual screen dimensions then people should size and place objects according to percentages of the _W & _H. Just makes more sense to me.
The only slight ‘issue’ I have with any scaling at all is that it can make pixel perfect alignment a slight issue. Maybe it’s best not to scale at all and work completely with percentages of the actual resolution?